This chapter delves into the ethical and regulatory considerations surrounding the implementation of Generative AI in nursing practice. Students will explore the potential risks and challenges, such as data privacy, bias, and accountability, associated with the use of Generative AI in healthcare. They will also examine the evolving regulatory landscape, including guidelines and policies established by healthcare governing bodies and professional nursing organizations. Students will gain an understanding of the importance of ethical decision-making, transparency, and patient-centered approaches when integrating Generative AI into nursing workflows.