In this chapter, we will introduce you to the world of G protein signaling, discussing its importance in cellular communication and providing a historical background of its discovery.

This chapter will delve into the structure and function of G proteins, explaining their components, activation mechanisms, and regulation.

In this chapter, we will focus on the Gi family of G proteins, discussing their structure, function, and role in various physiological processes, as well as their signaling pathways.

This chapter will explore the mechanisms of G protein coupling and dissociation, explaining the role of GTP in G protein activation and the process of G protein reassembly.

In the final chapter, we will discuss the implications of Gi protein dysfunction in human diseases and explore therapeutic interventions targeting Gi proteins.